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Inflammation and Immune Systems Bioengineering Lab

The Arnold Lab combines experimental and computational systems biology to unveil systems-level properties of immune cell communication networks and inflammatory tissue environments relevant to disease states.  We are especially interested in understanding how the complex balance of cytokine and growth factor cues known generally as “inflammation” underpin both productive physiological processes and also problematic pathologic tissue remodeling.  Our research program focuses on using theory- and data-driven computational approaches to infer cytokine networks driving cell behavior, tissue phenotype and disease progression.  We collaborate closely with clinicians to apply these approaches to human disease states, where they can provide new diagnostic biomarkers and give insight into complex mechanisms driving pathogenic processes.